The effect of the UGT1A1*28 allele on survival after irinotecan-based chemotherapy: a collaborative meta-analysis.
Identifieur interne : 003440 ( Main/Exploration ); précédent : 003439; suivant : 003441The effect of the UGT1A1*28 allele on survival after irinotecan-based chemotherapy: a collaborative meta-analysis.
Auteurs : M M Dias [Australie] ; J-P Pignon [France] ; C S Karapetis [Australie] ; V. Boige [France] ; B. Glimelius [Suède] ; D M Kweekel [Pays-Bas] ; P N Lara [États-Unis] ; P. Laurent-Puig [France] ; E. Martinez-Balibrea [Espagne] ; D. Páez [Espagne] ; C J A. Punt [Pays-Bas] ; M W Redman [États-Unis] ; G. Toffoli [Italie] ; M. Wadelius [Suède] ; R A Mckinnon [Australie] ; M J Sorich [Australie]Source :
- The pharmacogenomics journal [ 1473-1150 ] ; 2014.
Descripteurs français
- KwdFr :
- Allèles, Analyse de survie, Camptothécine (administration et posologie), Camptothécine (analogues et dérivés), Camptothécine (usage thérapeutique), Glucuronosyltransferase (génétique), Génotype, Humains, Protocoles de polychimiothérapie antinéoplasique (administration et posologie), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Tumeurs (génétique), Tumeurs (traitement médicamenteux), Évolution de la maladie.
- MESH :
- administration et posologie : Camptothécine, Protocoles de polychimiothérapie antinéoplasique.
- analogues et dérivés : Camptothécine.
- génétique : Glucuronosyltransferase, Tumeurs.
- traitement médicamenteux : Tumeurs.
- usage thérapeutique : Camptothécine, Protocoles de polychimiothérapie antinéoplasique.
- Allèles, Analyse de survie, Génotype, Humains, Évolution de la maladie.
English descriptors
- KwdEn :
- Alleles, Antineoplastic Combined Chemotherapy Protocols (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Camptothecin (administration & dosage), Camptothecin (analogs & derivatives), Camptothecin (therapeutic use), Disease Progression, Genotype, Glucuronosyltransferase (genetics), Humans, Neoplasms (drug therapy), Neoplasms (genetics), Survival Analysis.
- MESH :
- chemical , administration & dosage : Camptothecin.
- administration & dosage : Antineoplastic Combined Chemotherapy Protocols.
- chemical , analogs & derivatives : Camptothecin.
- drug therapy : Neoplasms.
- chemical , genetics : Glucuronosyltransferase, Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols, Camptothecin.
- Alleles, Disease Progression, Genotype, Humans, Survival Analysis.
Abstract
To date, studies of irinotecan pharmacogenetics have mostly focused on the effect of the UGT1A1*28 allele on irinotecan-related toxicity. However, the clinical utility of routine UGT1A1*28 genotyping to pre-emptively adjust irinotecan dosage is dependent upon whether UGT1A1*28 also affects patient survival following irinotecan therapy. Previous observational studies evaluating the influence of UGT1A1*28 on survival have shown contradictory results. A systematic review and meta-analysis of both published and unpublished data were performed to summarize the available evidence of the relationship between the UGT1A1*28 allele and patient survival related to irinotecan therapy. Overall and progression-free survival meta-analysis data were available for 1524 patients and 1494 patients, respectively. The difference in the survival between patients of different UGT1A1*28 genotypes (homozygous, heterozygous or wild-type) who had received irinotecan was not found to be statistically significant. There was also no evidence of irinotecan dose, regimen or line of therapy having an impact on this association.
DOI: 10.1038/tpj.2014.16
PubMed: 24709690
Affiliations:
- Australie, Espagne, France, Italie, Pays-Bas, Suède, États-Unis
- Californie, Catalogne, East Middle Sweden, Hollande-Méridionale, Hollande-Septentrionale, Svealand, Washington (État), Île-de-France
- Amsterdam, Barcelone, Leyde, Paris, Uppsala
- Université Paris-Descartes, Université d'Amsterdam, Université d'Uppsala
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Le document en format XML
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Punt</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Redman, M W" sort="Redman, M W" uniqKey="Redman M" first="M W" last="Redman">M W Redman</name><affiliation wicri:level="2"><nlm:affiliation>Lung and Cancer Control Committees, Fred Hutchinson Cancer Research Center, Statistical Center: SWOG, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lung and Cancer Control Committees, Fred Hutchinson Cancer Research Center, Statistical Center: SWOG, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Toffoli, G" sort="Toffoli, G" uniqKey="Toffoli G" first="G" last="Toffoli">G. 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Wadelius</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Mckinnon, R A" sort="Mckinnon, R A" uniqKey="Mckinnon R" first="R A" last="Mckinnon">R A Mckinnon</name><affiliation wicri:level="1"><nlm:affiliation>Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Sorich, M J" sort="Sorich, M J" uniqKey="Sorich M" first="M J" last="Sorich">M J Sorich</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia [2] Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia [2] Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24709690</idno><idno type="pmid">24709690</idno><idno type="doi">10.1038/tpj.2014.16</idno><idno type="wicri:Area/PubMed/Corpus">003408</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003408</idno><idno type="wicri:Area/PubMed/Curation">003296</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003296</idno><idno type="wicri:Area/PubMed/Checkpoint">003296</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003296</idno><idno type="wicri:Area/Ncbi/Merge">001946</idno><idno type="wicri:Area/Ncbi/Curation">001946</idno><idno type="wicri:Area/Ncbi/Checkpoint">001946</idno><idno type="wicri:Area/Main/Merge">003452</idno><idno type="wicri:Area/Main/Curation">003440</idno><idno type="wicri:Area/Main/Exploration">003440</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of the UGT1A1*28 allele on survival after irinotecan-based chemotherapy: a collaborative meta-analysis.</title><author><name sortKey="Dias, M M" sort="Dias, M M" uniqKey="Dias M" first="M M" last="Dias">M M Dias</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Pignon, J P" sort="Pignon, J P" uniqKey="Pignon J" first="J-P" last="Pignon">J-P Pignon</name><affiliation wicri:level="1"><nlm:affiliation>Meta-analysis Unit, Department of Biostatistics and Epidemiology, Gustave-Roussy, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Meta-analysis Unit, Department of Biostatistics and Epidemiology, Gustave-Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Karapetis, C S" sort="Karapetis, C S" uniqKey="Karapetis C" first="C S" last="Karapetis">C S Karapetis</name><affiliation wicri:level="1"><nlm:affiliation>Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Boige, V" sort="Boige, V" uniqKey="Boige V" first="V" last="Boige">V. Boige</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncologic Medicine, Gustave-Roussy, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oncologic Medicine, Gustave-Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Glimelius, B" sort="Glimelius, B" uniqKey="Glimelius B" first="B" last="Glimelius">B. Glimelius</name><affiliation wicri:level="4"><nlm:affiliation>Section of Oncology, Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Oncology, Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Kweekel, D M" sort="Kweekel, D M" uniqKey="Kweekel D" first="D M" last="Kweekel">D M Kweekel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lara, P N" sort="Lara, P N" uniqKey="Lara P" first="P N" last="Lara">P N Lara</name><affiliation wicri:level="2"><nlm:affiliation>Davis Comprehensive Cancer Center, University of California, Sacramento, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Davis Comprehensive Cancer Center, University of California, Sacramento, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Laurent Puig, P" sort="Laurent Puig, P" uniqKey="Laurent Puig P" first="P" last="Laurent-Puig">P. Laurent-Puig</name><affiliation wicri:level="4"><nlm:affiliation>Unité Mixte de Recherche S775, Institut National de la Santé et de la Recherche Médicale, Université Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S775, Institut National de la Santé et de la Recherche Médicale, Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Martinez Balibrea, E" sort="Martinez Balibrea, E" uniqKey="Martinez Balibrea E" first="E" last="Martinez-Balibrea">E. Martinez-Balibrea</name><affiliation wicri:level="1"><nlm:affiliation>Laboratori Biologia Molecular del Càncer, Institut Català d'Oncologia, Fundació Institut IGTP, Badalona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratori Biologia Molecular del Càncer, Institut Català d'Oncologia, Fundació Institut IGTP, Badalona</wicri:regionArea><wicri:noRegion>Badalona</wicri:noRegion></affiliation></author><author><name sortKey="Paez, D" sort="Paez, D" uniqKey="Paez D" first="D" last="Páez">D. Páez</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Punt, C J A" sort="Punt, C J A" uniqKey="Punt C" first="C J A" last="Punt">C J A. Punt</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Redman, M W" sort="Redman, M W" uniqKey="Redman M" first="M W" last="Redman">M W Redman</name><affiliation wicri:level="2"><nlm:affiliation>Lung and Cancer Control Committees, Fred Hutchinson Cancer Research Center, Statistical Center: SWOG, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lung and Cancer Control Committees, Fred Hutchinson Cancer Research Center, Statistical Center: SWOG, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Toffoli, G" sort="Toffoli, G" uniqKey="Toffoli G" first="G" last="Toffoli">G. Toffoli</name><affiliation wicri:level="1"><nlm:affiliation>Experimental and Clinical Pharmacology Unit, CRO-National Cancer Institute, Aviano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Experimental and Clinical Pharmacology Unit, CRO-National Cancer Institute, Aviano</wicri:regionArea><wicri:noRegion>Aviano</wicri:noRegion></affiliation></author><author><name sortKey="Wadelius, M" sort="Wadelius, M" uniqKey="Wadelius M" first="M" last="Wadelius">M. Wadelius</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Mckinnon, R A" sort="Mckinnon, R A" uniqKey="Mckinnon R" first="R A" last="Mckinnon">R A Mckinnon</name><affiliation wicri:level="1"><nlm:affiliation>Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Sorich, M J" sort="Sorich, M J" uniqKey="Sorich M" first="M J" last="Sorich">M J Sorich</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia [2] Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia [2] Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author></analytic><series><title level="j">The pharmacogenomics journal</title><idno type="eISSN">1473-1150</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Antineoplastic Combined Chemotherapy Protocols (administration & dosage)</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Camptothecin (administration & dosage)</term><term>Camptothecin (analogs & derivatives)</term><term>Camptothecin (therapeutic use)</term><term>Disease Progression</term><term>Genotype</term><term>Glucuronosyltransferase (genetics)</term><term>Humans</term><term>Neoplasms (drug therapy)</term><term>Neoplasms (genetics)</term><term>Survival Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term><term>Analyse de survie</term><term>Camptothécine (administration et posologie)</term><term>Camptothécine (analogues et dérivés)</term><term>Camptothécine (usage thérapeutique)</term><term>Glucuronosyltransferase (génétique)</term><term>Génotype</term><term>Humains</term><term>Protocoles de polychimiothérapie antinéoplasique (administration et posologie)</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Tumeurs (génétique)</term><term>Tumeurs (traitement médicamenteux)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Camptothecin</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Camptothécine</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Camptothecin</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Camptothécine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glucuronosyltransferase</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glucuronosyltransferase</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term><term>Camptothecin</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Camptothécine</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Disease Progression</term><term>Genotype</term><term>Humans</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Analyse de survie</term><term>Génotype</term><term>Humains</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To date, studies of irinotecan pharmacogenetics have mostly focused on the effect of the UGT1A1*28 allele on irinotecan-related toxicity. However, the clinical utility of routine UGT1A1*28 genotyping to pre-emptively adjust irinotecan dosage is dependent upon whether UGT1A1*28 also affects patient survival following irinotecan therapy. Previous observational studies evaluating the influence of UGT1A1*28 on survival have shown contradictory results. A systematic review and meta-analysis of both published and unpublished data were performed to summarize the available evidence of the relationship between the UGT1A1*28 allele and patient survival related to irinotecan therapy. Overall and progression-free survival meta-analysis data were available for 1524 patients and 1494 patients, respectively. The difference in the survival between patients of different UGT1A1*28 genotypes (homozygous, heterozygous or wild-type) who had received irinotecan was not found to be statistically significant. There was also no evidence of irinotecan dose, regimen or line of therapy having an impact on this association.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Suède</li><li>États-Unis</li></country><region><li>Californie</li><li>Catalogne</li><li>East Middle Sweden</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Svealand</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Leyde</li><li>Paris</li><li>Uppsala</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université d'Amsterdam</li><li>Université d'Uppsala</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Dias, M M" sort="Dias, M M" uniqKey="Dias M" first="M M" last="Dias">M M Dias</name></noRegion><name sortKey="Karapetis, C S" sort="Karapetis, C S" uniqKey="Karapetis C" first="C S" last="Karapetis">C S Karapetis</name><name sortKey="Mckinnon, R A" sort="Mckinnon, R A" uniqKey="Mckinnon R" first="R A" last="Mckinnon">R A Mckinnon</name><name sortKey="Sorich, M J" sort="Sorich, M J" uniqKey="Sorich M" first="M J" last="Sorich">M J Sorich</name></country><country name="France"><noRegion><name sortKey="Pignon, J P" sort="Pignon, J P" uniqKey="Pignon J" first="J-P" last="Pignon">J-P Pignon</name></noRegion><name sortKey="Boige, V" sort="Boige, V" uniqKey="Boige V" first="V" last="Boige">V. Boige</name><name sortKey="Laurent Puig, P" sort="Laurent Puig, P" uniqKey="Laurent Puig P" first="P" last="Laurent-Puig">P. Laurent-Puig</name></country><country name="Suède"><region name="Svealand"><name sortKey="Glimelius, B" sort="Glimelius, B" uniqKey="Glimelius B" first="B" last="Glimelius">B. Glimelius</name></region><name sortKey="Wadelius, M" sort="Wadelius, M" uniqKey="Wadelius M" first="M" last="Wadelius">M. Wadelius</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Kweekel, D M" sort="Kweekel, D M" uniqKey="Kweekel D" first="D M" last="Kweekel">D M Kweekel</name></region><name sortKey="Punt, C J A" sort="Punt, C J A" uniqKey="Punt C" first="C J A" last="Punt">C J A. Punt</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Lara, P N" sort="Lara, P N" uniqKey="Lara P" first="P N" last="Lara">P N Lara</name></region><name sortKey="Redman, M W" sort="Redman, M W" uniqKey="Redman M" first="M W" last="Redman">M W Redman</name></country><country name="Espagne"><noRegion><name sortKey="Martinez Balibrea, E" sort="Martinez Balibrea, E" uniqKey="Martinez Balibrea E" first="E" last="Martinez-Balibrea">E. Martinez-Balibrea</name></noRegion><name sortKey="Paez, D" sort="Paez, D" uniqKey="Paez D" first="D" last="Páez">D. Páez</name></country><country name="Italie"><noRegion><name sortKey="Toffoli, G" sort="Toffoli, G" uniqKey="Toffoli G" first="G" last="Toffoli">G. Toffoli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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